منابع مشابه
Group B streptococcal conjugate vaccines.
Linkage of bacterial capsular polysaccharides to proteins to create conjugate vaccines has had a dramatic impact on the health of children. Although unconjugated polysaccharides are poorly immunogenic in infants and some older children and adults, their covalent coupling with proteins stimulates T cell dependent antigenic recognition that profoundly enhances immunogenicity. In the decade since ...
متن کاملGroup B streptococcal type II and III conjugate vaccines: physicochemical properties that influence immunogenicity.
Recent efforts toward developing vaccines against group B streptococci (GBS) have focused on increasing the immunogenicity of GBS polysaccharides by conjugation to carrier proteins. However, partial depolymerization of GBS polysaccharides for the production of vaccines is a difficult task because of their acid-labile, antigenically critical sialic acids. Here we report a method for the partial ...
متن کاملConjugate vaccines against group B Streptococcus types IV and VII.
Although rarely encountered, group B Streptococcus (GBS) types IV and VII have been isolated from infants and adults with invasive disease. This study was designed to determine the immunogenicity and efficacy in animals of conjugate vaccines prepared with GBS types IV and VII capsular polysaccharide (CPS). Despite the striking similarities in structure of these 2 carbohydrate antigens, high-tit...
متن کاملMeningococcal group C conjugate vaccines
In November 1999 the Department of Health introduced a national vaccination programme using newly licensed meningococcal serogroup C conjugate vaccines (MenC). In the largest national mass vaccination campaign ever undertaken in the UK, all people under the age of 18 years are being oVered vaccination: three doses for infants as part of the primary vaccination schedule at 2, 3, and 4 months of ...
متن کاملMeningococcal group C conjugate vaccines
In November 1999 the Department of Health introduced a national vaccination programme using newly licensed meningococcal serogroup C conjugate vaccines (MenC). In the largest national mass vaccination campaign ever undertaken in the UK, all people under the age of 18 years are being oVered vaccination: three doses for infants as part of the primary vaccination schedule at 2, 3, and 4 months of ...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2003
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.88.5.375